COMPOSTO DE GRIGNARD PDF

5 jul. 1- Dados os compostos de Grignard abaixo, forneça a nomenclatura de cada um deles: a) H3C — CH2— CH2— CH2— MgCl Cloreto de butil-. Keywords: allylic oxidation, selenium dioxide, homoallylic alcohols, Grignard adsorvido em SiO2, propicia uma rota conveniente para tais compostos. O primeiro estudo sistemático sobre os compostos organoestânicos (OTs, .. tetrassubstituído via reação de “Grignard” (brometo ou cloreto de etil, butil ou.

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Environmental contamination for organotin compounds

The extracts griganrd dried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation. The occurrence and the effects of organotin compounds OTs have been studied since a long time, due to their widespread use and deleterious cimposto. To a stirred solution of 14 3. After 30 min, geranyl bromide 2. To stirred solution of 1. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Preparation of aromatic geraniol analogues via a Cu(I)-mediated Grignard coupling

Scheme 2 shows the first attempt. Em Organotin Compounds ; Sawyer, A. This result was still not satisfactory so we tried a different approach. Preparative column chromatography was carried using silica gel 60 Merckmesh. The mixture was stirred for 48 h. The organic layer was then dried over MgSO 4filtered and the solvent was removed under reduced pressure.

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New York,vol. To a solution of 10 3. The same procedure as employed for allylic oxidation of 1 was grginard ; compound 13 3.

Geraniol was purchased from Aldrich Chem. A new sequence was investigated with another substrate in an attempt to improve the yield of the desired phenol-alcohol 9 Scheme 4. To a solution of 2-iodophenol 2. The ether phase was washed with water 30 mLthen with brine 2×30 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation.

Preparation of aromatic geraniol analogues via a Cu I -mediated Grignard coupling. Bromination of geraniol 15 with phosphorus tribromide 0. How to cite this article.

The mixture was treated drop wise with cold metanol 1 mL and extracted with hexane. Grignaard Kascheres on occasion of his 60 th birthday. A wide variety of phenolic natural products contain isoprenoid residues. A solution of 2. To improve the low yield that was obtained for the oxidation of 8we investigated a new route to reach 9. Fall30 Also, we developed an efficient synthesis of 2-geranylphenol derivatives via a Cu I -mediated Grignard coupling of 2-lithiophenols and geranyl substrates.

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The solvent was removed under reduced pressure and the residue grinard diluted with ether 50 mL and water 30 mL and extracted with ether 2×50 mL. The solvent was removed under vacuum and the residue was diluted in ether 50 mL and water 30 mLthen extracted with ether 2×30 mLdried over MgSO 4 and filtered, and then the solvent was removed under reduced pressure.

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How to cite this article. Then BuLi in hexane 2. In a three necked round bottom flask, tert -butyldimethylsilyl 2-iodophenol ether 11 3. The extracts were washed with a saturated aqueous comoosto of FeSO 4. Our target was to obtain 2-[ 2 E ,6 E -3,7-dimethylhydroxy-2,6-octadienyl]phenol 9 by optimizing the coupling of geranyl acetate derivatives with more appropriate reagent O -protected 2-iodophenol. The organic comoosto was washed with two portions of brine then dried with anhydrous MgSO 4.